Association Between Helicobacter pylori, Adverse Gynecological and Pregnancy Outcomes, and Some Cancers: An Overview of Metanalyses

Context: The number of meta-analyses published about Helicobacter pylori-associated diseases that clinicians must comprehensively know are scarce. This overview aims to give comprehensive knowledge on the fascinating topic diseases. Methods: search strategy was systematically screen articles evaluating association between H. pylori infection and gynecological reproductive health issues cancers authentic databases Scopus, MEDLINE, Web Sciences from inception until 2022 Results: Fifteen were included in overview. infections significantly associated with general adverse pregnancy outcomes such as gestational diabetes mellitus, preeclampsia, hyperemesis gravidarum birth defect fetal growth restriction. not a deficiency micronutrients (B2, folate, ferritin) but an increased risk iron-deficiency anemia during pregnancy. In esophagus cancer, reduced adenocarcinoma esophageal squamous cell carcinoma. There no significant asthma. results also indicated elevated colorectal adenoma, asthma lung cancer. Results metanalysis consistently reproducible regarding spontaneous abortion pancreatic Conclusions: Our revealed relationship several cancers, namely colorectal, lung, well issues.